Teresa Jagla

Drosophila ryanodine receptor gene triggers functional and developmental muscle properties and could be used to assess the impact of human RYR1 mutations

This study shows that the Drosophila RYR gene is essential for muscle development and function and demonstrates its utility in assessing human RYR1 mutations.

Deregulations of miR-1 and its target Multiplexin promote dilated cardiomyopathy associated with myotonic dystrophy type 1

This study identifies miR-1 and its target Multiplexin as key regulators in DM1-associated dilated cardiomyopathy using Drosophila models.

Gelsolin and dCryAB act downstream of muscle identity genes and contribute to preventing muscle splitting and branching in Drosophila

The paper identifies Gelsolin and dCryAB as downstream effectors of muscle identity genes that prevent muscle splitting and branching in Drosophila.

Straightjacket/α 2δ 3 deregulation is associated with cardiac conduction defects in Myotonic Dystrophy type 1

The paper identifies straightjacket/α2δ3 deregulation as a contributor to cardiac conduction defects in DM1 by showing its overexpression in fly models and human patients.