Yoan Renaud

Enhanced Multiplexed Single-Cell RNA-Sequencing for Accurate Detection of Treatment Effects Without Batch Correction in the Avian Embryonic Model

The paper develops a species-agnostic multiplexing method for single-cell RNA sequencing in chick embryos, enabling accurate detection of treatment effects without batch correction.

Amalgam plays a dual role in controlling the number of leg muscle progenitors and regulating their interactions with developing tendon

The paper identifies Amalgam and Neurotactin as molecular mediators of cell-cell communication between leg muscle and tendon precursors in Drosophila.

A dual histone code specifies the binding of heterochromatin protein Rhino to a subset of piRNA source loci

The paper identifies a dual histone modification (H3K9me3 and H3K27me3) that specifies Rhino binding to a subset of piRNA source loci in Drosophila germ cells, independent of Kipferl.

Adenine methylation is very scarce in the drosophila genome and not erased by the Ten Eleven Translocation dioxygenase.

The paper investigates 6mA DNA modification in drosophila, finding it present at very low levels and not erased by TET, suggesting TET acts non-enzymatically.

Gap junction and amino acid import in somatic cells promote germ cell growth

The paper shows that gap junctions and amino acid import in somatic cells support germ cell growth in Drosophila by enabling metabolic transfer and regulating translation.

Deregulations of miR-1 and its target Multiplexin promote dilated cardiomyopathy associated with myotonic dystrophy type 1

This study identifies miR-1 and its target Multiplexin as key regulators in DM1-associated dilated cardiomyopathy using Drosophila models.

A Nanog-dependent gene cluster initiates the specification of the pluripotent epiblast

This study identifies a Nanog-dependent gene cluster that initiates epiblast specification in early mouse embryos, revealing a primary heterogeneity independent of NANOG, GATA6, and FGF signaling.

Characterization of the Drosophila adult hematopoietic system reveals a rare cell population with differentiation and proliferation potential.

The paper characterizes the Drosophila adult hematopoietic system, identifying a rare cell population with differentiation and proliferation potential in response to infection.

m6A RNA methylation regulates promoter proximal pausing of RNA Polymerase II

This study shows that m6A RNA methylation regulates RNAP II promoter-proximal pausing, affecting gene expression and transcription.

Differential activation of JAK-STAT signaling in blood cell progenitors reveals functional compartmentalization of the Drosophila lymph gland.

The paper identifies functional differences in JAK-STAT signaling between anterior and posterior progenitors in the Drosophila lymph gland, showing how compartmentalization affects immune response.

Gelsolin and dCryAB act downstream of muscle identity genes and contribute to preventing muscle splitting and branching in Drosophila

The paper identifies Gelsolin and dCryAB as downstream effectors of muscle identity genes that prevent muscle splitting and branching in Drosophila.

Straightjacket/α 2δ 3 deregulation is associated with cardiac conduction defects in Myotonic Dystrophy type 1

The paper identifies straightjacket/α2δ3 deregulation as a contributor to cardiac conduction defects in DM1 by showing its overexpression in fly models and human patients.