Origin and Correlates of Viral Rebound in SIV-Infected Rhesus Macaques Following ART Discontinuation
Irena V. King, Malika Aïd, Emek Köse, Taina T. Immonen, Charles A. Goodman, Christine M. Fennessey, Alessandro Colarusso, Victoria E. K. Walker-Sperling, Erica N. Borducchi, Romas Geleziunas, William J. Rinaldi, Melissa J. Ferguson, Louis J. Picker, Jeffrey D. Lifson, Brandon F. Keele, Dan H. Barouch
This study identifies the origin and dynamics of viral rebound in SIV-infected macaques after ART discontinuation, showing local tissue replication and systemic expansion of clonal lineages.
bioRxiv · Aug 30, 2025 · PreprintMicrobiology