Author

Annie Trinh

University of California, IrvineORCID 0000-0002-9320-4891Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Organism:human· 1 Assay:long-read sequencing· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

Elizabeth L. ReadiD· 2 shared Kwadwo BonsuiD· 2 shared Nandor LaszikiD· 2 shared Timothy L. DowningiD· 2 shared Alexander A. GimelbrantiD· 1 shared Asia MendelevichiD· 1 shared Julien L. P. MorivaliD· 1 shared Justin E. Vega· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenomics

Elizabeth L. ReadORCID

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2 papers

Recent·Most cited

A Tunable, Ultrasensitive Threshold in Enzymatic Activity Governs the DNA Methylation Landscape

Kwadwo Bonsu, Nandor Laszik, Annie Trinh, Timothy L. Downing, Elizabeth L. Read

The paper investigates how enzymatic activity thresholds control DNA methylation patterns, finding an ultrasensitive switch mechanism influenced by enzyme interactions.

Biophysical Journal · Mar 10, 2026Peer-reviewedGenomics

Methylation pseudotime analysis for label-free profiling of the temporal chromatin landscape with long-read sequencing

Annie Trinh, Navied Akhtar, Kwadwo Bonsu, Nandor Laszik, Asia Mendelevich, Tanye Wen, Julien L. P. Morival, Katelyn E. Diune, Mitchell Frazeur, Justin E. Vega, Alexander A. Gimelbrant, Elizabeth L. Read, Timothy L. Downing

This paper introduces MPATH, a method to temporally order epigenetic modifications using long-read sequencing, revealing sub-cell-cycle dynamics of methylation states and nucleosome occupancy.

bioRxiv · Mar 3, 2025 · PreprintGenomics