Nandor Laszik

A Tunable, Ultrasensitive Threshold in Enzymatic Activity Governs the DNA Methylation Landscape

The paper investigates how enzymatic activity thresholds control DNA methylation patterns, finding an ultrasensitive switch mechanism influenced by enzyme interactions.

Scalable Inference and Identifiability of Kinetic Parameters for Transcriptional Bursting from Single Cell Data

This paper develops a computational pipeline to infer kinetic parameters from single-cell RNA sequencing data and assesses parameter identifiability using the stochastic telegraph model.

Methylation pseudotime analysis for label-free profiling of the temporal chromatin landscape with long-read sequencing

This paper introduces MPATH, a method to temporally order epigenetic modifications using long-read sequencing, revealing sub-cell-cycle dynamics of methylation states and nucleosome occupancy.