Alexander A. Gimelbrant

This study identifies how IFN and mimetics prevent TB susceptibility by modulating iron metabolism and lipid peroxidation in macrophages.

This paper introduces MPATH, a method to temporally order epigenetic modifications using long-read sequencing, revealing sub-cell-cycle dynamics of methylation states and nucleosome occupancy.

This study identifies Myc dysregulation in macrophages as a driver of TB susceptibility by linking lipid peroxidation and IFN-I pathway hyperactivity.

The paper introduces a spike-in method to improve allele-specific expression analysis by reducing technical noise and cost.

This study uses single-cell RNA sequencing to analyze developing and mature glia in peripheral sensory ganglia, revealing transcriptional differences and shared molecular features across glial subtypes.

The paper investigates the persistence of allelic expression patterns in murine hematopoietic stem cells and their differentiated B-cell clones, finding that most allele-specific transcriptional states are established de novo during differentiation.

The paper identifies DNA methylation as a key mechanism for maintaining monoallelic expression on autosomes and reveals its tunable control of allele-specific expression.

The paper assesses allelic imbalance variability in RNA sequencing and finds technical replicates show up to 7-fold higher variation than expected, which can be mitigated to improve differential analysis.

MaGIC identifies monoallelic expressed genes using chromatin signatures from ChIP-seq data, providing a tool for analyzing MAE in human and mouse cells.