Author

James B. Hayes

Vanderbilt UniversityORCID 0000-0002-9321-212XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 1 Organism:zebrafish· 1

Frequent Co-Authors

Alaina H. WilletiD· 2 shared Dylan Tyler BurnetteiD· 2 shared Abigail C. NeiningeriD· 1 shared Anna M. Bainbridge· 1 shared Cynthia A. Reinhart‐KingiD· 1 shared David ArmstrongiD· 1 shared Dharmendra ChoudharyiD· 1 shared Dylan RitteriD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersCell Biology

Alaina H. WilletORCID

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2 papers

Recent·Most cited

Cell BiologyCirculation ResearchPeer-reviewedNov 19, 2025

A non-muscle α-actinin is an intrinsic component of the cardiac Z-disc and regulates sarcomere turnover, contractility, and heart remodeling

James B. Hayes, Dharmendra Choudhary, Dylan Ritter…·Dylan Tyler Burnette

This study identifies ACTN4 as a non-muscle α-actinin in cardiac sarcomeres, showing it regulates contractility, hypertrophy, and heart remodeling without disease hallmarks.

6 citations

humanzebrafish

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Cell BiologyMolecular Biology of the CellPeer-reviewedSep 10, 2025

Alpha-actinin-1 stabilizes focal adhesions to facilitate sarcomere assembly in cardiac myocytes

James B. Hayes, Anna M. Bainbridge, Alaina H. Willet, Dylan Tyler Burnette

This study shows ACTN1 is essential for sarcomere assembly in cardiac myocytes by stabilizing focal adhesions, distinct from ACTN2's role at Z-discs.

3 citations

humanproteomics

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