A non-muscle α-actinin is an intrinsic component of the cardiac Z-disc and regulates sarcomere turnover, contractility, and heart remodeling
James B. Hayes, Dharmendra Choudhary, Dylan Ritter, Abigail C. Neininger, Alaina H. Willet, Leah R. Caplan, Yu Wang, Xiao Liu, Nilay Taneja, Zachary Sanchez, Kyra Smart, David Armstrong, Cynthia A. Reinhart‐King, Qi Liu, Matthew J. Tyska, , Dylan Tyler Burnette
This study identifies ACTN4 as a non-muscle α-actinin in cardiac sarcomeres, showing it regulates contractility, hypertrophy, and heart remodeling without disease hallmarks.
Circulation Research · Nov 19, 2025Peer-reviewedCell Biology