Next-gen glycoengineering: combining cellular and metabolic engineering to fine tune mAb β1,4-galactosylation
Apostolos Tsopanoglou, Mina Ghahremanzamaneh, Itzcóatl A. Gómez, Kallum Doyle, Brian Glennon, Sara Carillo, Jonathan Bones, Ioscani Jiménez del Val
This paper combines metabolic and cellular glycoengineering to control mAb β1,4-galactosylation, achieving broad tunable control and improved pharmacological activity.
bioRxiv · Sep 28, 2026 · PreprintBioengineering