The paper quantifies how interstitial telomeric sequences (ITSs) increase gross chromosomal rearrangement (GCR) rates in yeast through multiple mechanisms involving replication, repair, and telomere maintenance.

9 citations

yeaststatistical model

𝕏 PostBluesky

Molecular BiologyGeneticsPeer-reviewedSep 12, 2024

Revisiting the role of the spindle assembly checkpoint in the formation of gross chromosomal rearrangements in Saccharomyces cerevisiae

Yue Yao, Ziqing Yin, Fernando Rodrigo Rosas Bringas…·Michael Chang

The paper revisits the role of the spindle assembly checkpoint in promoting gross chromosomal rearrangements in yeast and finds no such role after correcting for experimental artifacts.

3 citations

yeastexperimental assay

𝕏 PostBluesky

Molecular BiologybioRxivPreprintFeb 3, 2023

Deletion of MEC1 suppresses replicative senescence of the cdc13-2 mutant in Saccharomyces cerevisiae

Yue Yao, Enikö Fekete-Szücs, Fernando Rodrigo Rosas Bringas, Michael Chang

The paper shows that deleting MEC1 suppresses replicative senescence in cdc13-2 yeast cells, which is dependent on telomerase activity.

DOI 10.1101/2023.02.03.527016

yeastexperimental assay

𝕏 PostBluesky