Michael Chang

The role of the nuclear pore complex in the stability of disease-related short tandem DNA repeats

This study shows disease-related short tandem repeats relocate to nuclear pore complexes, with implications for genome stability and repeat dynamics.

Both Genome Instability and Replicative Senescence Stem from the Shortest Telomere in Telomerase-Negative Cells

The paper identifies a threshold telomere length in telomerase-negative cells that triggers replicative senescence and genomic instability through dysfunction of the shortest telomere.

DCX Enhances Glioblastoma Metabolism Through Synergistic Regulation of Glutamine Synthesis and Metabolism-Related Genes for Cellular Homeostasis

This study shows DCX enhances glioblastoma metabolism by regulating glutamine synthesis and metabolism-related genes, supporting tumor proliferation through energy homeostasis.

Interstitial telomeric sequences promote gross chromosomal rearrangement via multiple mechanisms

The paper quantifies how interstitial telomeric sequences (ITSs) increase gross chromosomal rearrangement (GCR) rates in yeast through multiple mechanisms involving replication, repair, and telomere maintenance.

Revisiting the role of the spindle assembly checkpoint in the formation of gross chromosomal rearrangements in Saccharomyces cerevisiae

The paper revisits the role of the spindle assembly checkpoint in promoting gross chromosomal rearrangements in yeast and finds no such role after correcting for experimental artifacts.

Deletion of MEC1 suppresses replicative senescence of the cdc13-2 mutant in Saccharomyces cerevisiae

The paper shows that deleting MEC1 suppresses replicative senescence in cdc13-2 yeast cells, which is dependent on telomerase activity.

Rif2 protects Rap1-depleted telomeres from MRX-mediated degradation in Saccharomyces cerevisiae

This study shows Rif2 protects Rap1-depleted telomeres from MRX-mediated degradation in yeast, revealing parallel mechanisms to prevent telomere degradation.

Suppression of cdc13-2-associated senescence by pif1-m2 requires Ku-mediated telomerase recruitment

The paper shows that pif1-m2 mutation suppresses cdc13-2 senescence by enhancing yKu-TLC1 telomerase recruitment.

A synthetic lethal screen identifies HDAC4 as a potential target in MELK overexpressing cancers

The paper identifies HDAC4 as a synthetic lethal target in MELK-overexpressing cancers through a yeast screen and mammalian validation.

A genome-wide screen for genes affecting spontaneous direct-repeat recombination in Saccharomyces cerevisiae

The paper identifies 35 genes that, when deleted, cause hyper-recombination between direct repeats in yeast, including mismatch repair genes and DNA replication factors.

A genome-wide screen identifies genes that suppress the accumulation of spontaneous mutations in young and aged yeast cells

The paper identifies genes that suppress spontaneous mutation accumulation in yeast cells, finding PEX19 as an age-specific mutation suppressor.

Double-strand breaks are not the main cause of spontaneous sister chromatid exchange in wild-type yeast cells

This study uses Strand-seq to show that most spontaneous sister chromatid exchanges in yeast are not caused by DNA double-strand breaks.