Fernando Rodrigo Rosas Bringas

The paper identifies a threshold telomere length in telomerase-negative cells that triggers replicative senescence and genomic instability through dysfunction of the shortest telomere.

The paper quantifies how interstitial telomeric sequences (ITSs) increase gross chromosomal rearrangement (GCR) rates in yeast through multiple mechanisms involving replication, repair, and telomere maintenance.

The paper revisits the role of the spindle assembly checkpoint in promoting gross chromosomal rearrangements in yeast and finds no such role after correcting for experimental artifacts.

The paper shows that deleting MEC1 suppresses replicative senescence in cdc13-2 yeast cells, which is dependent on telomerase activity.

This study shows Rif2 protects Rap1-depleted telomeres from MRX-mediated degradation in yeast, revealing parallel mechanisms to prevent telomere degradation.

The paper shows that pif1-m2 mutation suppresses cdc13-2 senescence by enhancing yKu-TLC1 telomerase recruitment.

The paper identifies HDAC4 as a synthetic lethal target in MELK-overexpressing cancers through a yeast screen and mammalian validation.