Accounting for age-of-onset and family history improves power in genome-wide association studies
Emil M. Pedersen, Esben Agerbo, Oleguer Plana‐Ripoll, Jakob Grove, Julie Werenberg Dreier, Katherine Louise Musliner, Marie Bækvad‐Hansen, Georgios I. Athanasiadis, Andrew Joseph Schork, Jonas Bybjerg‐Grauholm, DAVID MICHAEL HOUGAARD, Thomas Mears Werge, Merete Nordentoft, Ole N Mors, Søren Dalsgaard, , Bjarni Jóhann Vilhjálmsson
This paper introduces LT-FH++, a method that improves GWAS power by incorporating age-of-onset and family history, showing increased significant associations in psychiatric disorders and mortality data.
The American Journal of Human Genetics · Feb 8, 2022Peer-reviewedBioinformatics