Author

Denghong Zhang

BioNano Genomics (United States)ORCID 0000-0002-9342-9978Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:variant calling· 2 Assay:DNA methylation· 1 Research Focus:genome assembly· 1 Organism:human· 1 Organism:mouse· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Alex R. HastieiD· 2 shared Saki ChaniD· 2 shared Chun-Long CheniD· 1 shared David M. GilbertiD· 1 shared Ernest T. Lam· 1 shared Guangtong JiangiD· 1 shared Han CaoiD· 1 shared Huaxi XuiD· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersGenomics

Alex R. HastieORCID

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3 papers

Recent·Most cited

Downregulating PTBP1 fails to convert astrocytes into hippocampal neurons and to alleviate symptoms in Alzheimer's mouse models

Tiantian Guo, Xinjia Pan, Guangtong Jiang, Denghong Zhang, Jinghui Qi, Lin Shao, Zhanxiang Wang, Huaxi Xu, Yingjun Zhao

This study shows that reducing PTBP1 in astrocytes does not convert them into neurons or improve Alzheimer's symptoms in mouse models.

Journal of Neuroscience · Aug 9, 2022Peer-reviewedNeuroscience

CRISPR-bind: a simple, custom CRISPR/dCas9-mediated labeling of genomic DNA for mapping in nanochannel arrays

Denghong Zhang, Saki Chan, Kenneth Sugerman, Joyce Lee, Ernest T. Lam, Sven Bocklandt, Han Cao, Alex R. Hastie

The paper introduces CRISPR-bind, a method using dCas9 to directly label genomic DNA with fluorescent CRISPR-dCas9 complexes for improved mapping and analysis.

bioRxiv · Jul 19, 2018 · PreprintGenomics

Genome-Wide Identification of Early-Firing Human Replication Origins by Optical Replication Mapping

Kyle N. Klein, Weitao Wang, Tyler M. Borrman, Saki Chan, Denghong Zhang, Zhiping Weng, Alex R. Hastie, Chun-Long Chen, David M. Gilbert, Nick Rhind

This study identifies early-firing human replication origins in HeLa cells using Optical Replication Mapping, revealing that initiation occurs across broad zones rather than confined to efficient origins.

bioRxiv · Nov 6, 2017 · PreprintGenomics