Saki Chan

Improved Aedes aegypti mosquito reference genome assembly enables biological discovery and vector control

The paper presents an improved Aedes aegypti genome assembly, AaegL5, which enhances biological understanding and vector control efforts by resolving key genomic features and identifying new targets for intervention.

CRISPR-bind: a simple, custom CRISPR/dCas9-mediated labeling of genomic DNA for mapping in nanochannel arrays

The paper introduces CRISPR-bind, a method using dCas9 to directly label genomic DNA with fluorescent CRISPR-dCas9 complexes for improved mapping and analysis.

Genome-Wide Identification of Early-Firing Human Replication Origins by Optical Replication Mapping

This study identifies early-firing human replication origins in HeLa cells using Optical Replication Mapping, revealing that initiation occurs across broad zones rather than confined to efficient origins.

Single-molecule sequencing and conformational capture enable de novo mammalian reference genomes

This paper presents a de novo mammalian genome assembly for the domestic goat using long-read sequencing, short-read validation, and chromatin interaction mapping, achieving high contiguity and resolving repetitive regions.