Discovery of Selective Small-Molecule Ligands of SV2C by AI-Enhanced Virtual Screening and Experimental Validation
Alexander C. Brueckner, Matthew F. Martin, Sheenam Khuttan, Benjamin J. Shields, Anshumali Mittal, Jennifer A. Schreiber, Romelia Salomón–Ferrer, Andrea Bortolato, Ali Salahpour, Meghan L. Bucher, Jonathan A. Coleman, Gary Wright Miller
This paper identifies selective SV2C ligands using AI-enhanced virtual screening and experimental validation, finding 22 active molecules with high selectivity over SV2A and SV2B.
bioRxiv · Sep 22, 2026 · PreprintNeuroscience