Ali Salahpour

This paper identifies selective SV2C ligands using AI-enhanced virtual screening and experimental validation, finding 22 active molecules with high selectivity over SV2A and SV2B.

The paper characterizes a Grin1Q536R/+ mouse model carrying a GRIN1 variant, showing age- and sex-dependent behavioral and physiological changes linked to GRIN1-NDD.

This study creates a mouse model of DTDS with the A313V DAT variant and identifies two potential treatments, [a]MPT and AMPH, that reduce hyperactivity.

This study shows that combining haloperidol with UNC9994 reduces schizophrenia-like symptoms in NMDAR-deficient mice.

This study investigates the effects of the GRIN1 Y647S variant in mice, showing that β-hydroxybutyrate reduces convulsions associated with the variant.

This study shows that restoring WAVE-1 in GluN1 knockdown mice rescues striatal spine density and improves maze exploration behavior.

This study shows that restoring NMDAR function in adult mice with congenital NMDAR deficiency improves cognitive behaviors, suggesting potential for adult treatment of related disorders.

This study shows that increased tyrosine hydroxylase activity in mice leads to higher dopamine levels, amphetamine response, and oxidative stress markers, suggesting a potential mechanism for neurodegeneration in Parkinson's disease.