Gary Wright Miller

This study identifies TCE metabolites in mice following inhalation exposure and finds DCA, TCA, and TCEOH-gluc as the most prevalent metabolites, with novel pathway perturbations observed.

This paper identifies selective SV2C ligands using AI-enhanced virtual screening and experimental validation, finding 22 active molecules with high selectivity over SV2A and SV2B.

This study presents cryo-EM structures of SV2C and its ligands, revealing structural differences that explain ligand selectivity and impact dopamine release.

CoxMDS identifies causal mediators in DNA methylation studies with survival outcomes, maintaining FDR control and higher power than existing methods.

The paper identifies sex- and Alzheimer's disease stage-specific genetic regulators of plasma metabolites and their associations with biomarkers.

This study shows that low-dose developmental exposure to deltamethrin disrupts molecular pathways related to circadian rhythms and MAP kinase in mouse brains, linking it to ADHD-like behaviors.

This study investigates how dopamine production and storage affect body size, development, and behavior in C. elegans, finding that increased dopamine production can rescue deficits caused by reduced dopamine sequestration.

This study shows that developmental exposure to pyrethroid pesticide deltamethrin disrupts brain metabolism in adult male mice, affecting folate, retinol, tryptophan, and dopamine signaling pathways.

This study shows that SV2C enhances dopamine and neurotoxicant storage in vesicles, reducing dopaminergic neuron vulnerability.

The paper analyzes bulk RNA-seq data from diverse ethnic groups to identify differentially expressed genes and pathways in Alzheimer's Disease, highlighting cross-ethnic and ethnic-specific findings.

This paper identifies swip-10's role in systemic copper homeostasis in C. elegans, linking it to mitochondrial function, oxidative stress, and neurodegeneration.

This study identifies biotin pathway dysregulation as a key mechanism linking manganese toxicity to Parkinson's disease using Drosophila and human iPSC models, showing biotin supplementation rescues neurotoxic phenotypes.

This study identifies VGLUT-mediated mechanisms protecting DA neurons from PD-related degeneration, revealing sex-specific effects and transcriptional regulators.

The paper develops MR-SPI, a Mendelian randomization method integrated with AlphaFold3 to identify causal protein biomarkers and predict 3D structural changes in Alzheimer's disease.

The paper introduces GAIT-GM, a Galaxy tool for multi-omics analysis, and finds a link between branched-chain amino acid metabolism and cholinergic neuron defects in a C. elegans Parkinson's disease model.

This study investigates the effects of reduced VMAT activity in C. elegans, showing increased sensitivity to MPP+ and metabolic changes, suggesting conserved monoamine function and potential for metabolomics in disease research.

This study shows that metabolic defects in C. elegans lead to hyperactive mitochondria and Parkinson's-like traits, with metformin improving motor function and reducing neurodegeneration.

This study compares the effects of selective D2 and D3 receptor antagonists on cocaine-induced behaviors in mice, finding opposite modulatory effects on locomotor activity and dopamine signaling.

This study uses metabolomics to identify metabolic differences between Parkinson’s disease and control patients, highlighting the impact of levodopa on observed variations.

This study shows that increased tyrosine hydroxylase activity in mice leads to higher dopamine levels, amphetamine response, and oxidative stress markers, suggesting a potential mechanism for neurodegeneration in Parkinson's disease.