IL-1β/IRAK4 Axis Promotes Ovarian Tumor Development at the Mesothelium Injury Sites
John P. Miller, Kyukwang Kim, Negar Khazan, Cameron W. A. Snyder, Niloy A. Singh, Elizabeth Lamere, Myla S. Strawderman, Sonali Sharma, Ronald Lakony, Michelle Whittum, Mark Anderson, Rick Keenan, Elizabeth Pritchett, Cameron D. Baker, John M. Ashton, , Rakesh K. Singh
This paper develops a MIM model to study EOC metastasis at mesothelial injury sites and shows IRAK4 inhibitors reduce tumor burden more effectively than IL-1/IL-1R1 targeting agents.
bioRxiv · Mar 18, 2025 · PreprintCancer Biology