Author

Roshan Shrestha

Lyon 1 UniversitéORCID 0000-0002-9356-5136Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Alexandre ChenaliD· 1 shared Amiel Abettan· 1 shared Benjamin BardiauxiD· 1 shared Corentin C. LegeriD· 1 shared Daniel LadantiD· 1 shared Dorothée Raoux‐Barbot· 1 shared François BontemsiD· 1 shared Gaia Scilironi· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiophysics

Alexandre ChenalORCID

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1 paper

Recent·Most cited

Post-translational acylation drives folding and activity of the CyaA bacterial toxin.

Corentin C. Leger, Samuel Hoff, Gaia Scilironi, Amiel Abettan, Roshan Shrestha, Jacinthe Frangieh, Vincent Deruelle, Nicolas Carvalho, Dorothée Raoux‐Barbot, Nathalie Duclert‐Savatier, Benjamin Bardiaux, Sébastien Brier, François Bontems, Gérard Pehau‐Arnaudet, Daniel Ladant, , Alexandre Chenal

This study shows that acylation stabilizes the native fold of CyaA and facilitates its membrane orientation, revealing how post-translational modification drives toxin activity.

bioRxiv · Sep 11, 2025 · PreprintBiophysics