Author

Amiel Abettan

University of Helsinki

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Assay:cryo-EM· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Vivek SharmaiD· 3 shared Esa‐Pekka KumpulaiD· 2 shared Evans EshriewiD· 2 shared Juha T. HuiskoneniD· 2 shared Shiv K. Sah‐TeliiD· 2 shared Alexandre ChenaliD· 1 shared Amina DjurabekovaiD· 1 shared Ashwini KedariiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersBiophysics

Vivek SharmaORCID

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Author profile →

4 papers

Recent·Most cited

Conformational dynamics of ND2 antiporter-like subunit in intact and truncated complex I

Amiel Abettan, Jonathan Lasham, Erik Endres, Vivek Sharma

This study uses molecular dynamics simulations to investigate conformational changes in the ND2 subunit of complex I, revealing a previously unobserved structural transition linked to proton pumping.

bioRxiv · Oct 4, 2026 · PreprintBiophysics

In situ Structure of the Human Gap Junction

Evans Eshriew, Esa‐Pekka Kumpula, Shiv K. Sah‐Teli, Amiel Abettan, Amina Djurabekova, Vivek Sharma, Juha T. Huiskonen

The paper determines the in situ structure of human Cx43 gap junction plaques using cryogenic electron tomography, revealing the role of the C-terminal domain in plaque assembly.

Science Advances · May 13, 2026Peer-reviewedCell Biology

Gating Mechanism of the Human Connexin 45 Gap Junction Channel

Shiv K. Sah‐Teli, Evans Eshriew, Amiel Abettan, Ashwini Kedari, Esa‐Pekka Kumpula, Jeffrey E. Saffitz, Vivek Sharma, Juha T. Huiskonen

This study determines the structural basis of Cx45 gating and Ca2+ regulation using cryo-EM, revealing a dual steric-electrostatic mechanism.

bioRxiv · May 7, 2026 · PreprintBiochemistry

Post-translational acylation drives folding and activity of the CyaA bacterial toxin.

Corentin C. Leger, Samuel Hoff, Gaia Scilironi, Amiel Abettan, Roshan Shrestha, Jacinthe Frangieh, Vincent Deruelle, Nicolas Carvalho, Dorothée Raoux‐Barbot, Nathalie Duclert‐Savatier, Benjamin Bardiaux, Sébastien Brier, François Bontems, Gérard Pehau‐Arnaudet, Daniel Ladant, , Alexandre Chenal

This study shows that acylation stabilizes the native fold of CyaA and facilitates its membrane orientation, revealing how post-translational modification drives toxin activity.

bioRxiv · Sep 11, 2025 · PreprintBiophysics