Alexandre Chenal

Covalently linked peptides and membrane potential enable CyaA segment translocation

This study investigates the translocation mechanisms of two CyaA-derived peptides, showing that P454 translocates independently of membrane potential while P233 requires a negative potential, and their covalent linkage enables translocation without potential.

A Seven-Protein Assembly Promotes Stability, Neutralisation and Secretion of the T7SSb LXG-effector TelE

The paper identifies a seven-protein complex that stabilizes and facilitates the secretion of the T7SSb effector TelE in SGG.

Post-translational acylation drives folding and activity of the CyaA bacterial toxin.

This study shows that acylation stabilizes the native fold of CyaA and facilitates its membrane orientation, revealing how post-translational modification drives toxin activity.