Nicolas Carvalho

The paper identifies Ldb17 as the on-switch for endocytic actin assembly in S. cerevisiae, revealing its complex regulation by Sla1 and evolutionary divergence from Dip1 in S. pombe.

This study investigates the translocation mechanisms of two CyaA-derived peptides, showing that P454 translocates independently of membrane potential while P233 requires a negative potential, and their covalent linkage enables translocation without potential.

This study shows that acylation stabilizes the native fold of CyaA and facilitates its membrane orientation, revealing how post-translational modification drives toxin activity.