Johannes A. Zuber

This study identifies BAP18 as a substrate of MAGE-A3/6, showing its degradation promotes cancer cell migration in both cell lines and human tissues.

The paper uses CRISPR screens to identify regulators of immunosuppressive surface molecules in cancer cells, finding DNAJC13 as a key regulator that enhances T-cell sensitivity and tumor survival.

The paper identifies AKIRIN2 as a multivalent adaptor protein that coordinates proteasome nuclear import through a stepwise assembly of importin clusters.

This study identifies PARG as a therapeutic target in colorectal cancer, showing that its inhibition synergizes with 5FU and irinotecan to improve treatment efficacy.

This paper describes the engineering of a molecular switch that controls CARs and transcription factors using an orally available drug, demonstrating tight regulation in vitro and in vivo.

This study shows MECOM represses myeloid differentiation by inhibiting CEBPA, and its overexpression in AML reduces CEBPA levels, maintaining stem cell state.

This paper develops caffeine-responsive switches for CAR T cells, showing they can be controlled by caffeine and effectively clear tumors in mice.

The paper identifies ERH and associated factors as post-transcriptional regulators of JAK2 mRNA maturation, essential for IFNγ signaling and innate immunity.

The paper determines how the human 26S proteasome distinguishes between K48-linked and K11/K48-branched ubiquitin chains through structural analysis and functional studies.

The paper investigates the assembly and functional resilience of the RNA exosome in mouse embryonic stem cells using CRISPR/Cas9, revealing a hierarchical assembly pathway and quality control mechanisms.

This paper introduces ARTi, a method using synthetic shRNAs to achieve precise and controllable RNAi for gene suppression.

This paper presents an improved RT-LAMP assay for SARS-CoV-2 detection that is rapid, sensitive, and suitable for both laboratory and home testing.

The paper investigates chromosomal contacts between promoters and enhancers using Capture Hi-C, showing that cohesin depletion affects long-range contacts but not shorter-range ones.

SLAM-ITseq enables transcriptome analysis of specific cell types in tissues without prior sorting, providing accurate in vivo transcriptional snapshots.

This study demonstrates that CTCF, WAPL, and PDS5 proteins regulate TADs and loops by controlling cohesin's interaction with chromatin.

SLAM-seq enables RNA polymerase II-dependent gene expression dynamics analysis by detecting 4-thiouridine incorporation at single-nucleotide resolution in mouse embryonic stem cells.