Florence L. Marlow

Microglia and Chek2 contribute to sex-specific organization of the adult zebrafish brain

The paper identifies microglia and Chek2 as factors contributing to sex-specific brain organization in adult zebrafish, with implications for sex-biased neurological disorders.

Clonal analysis reveals differential PGC contributions to the early germline and ovarian reserve

The paper shows that individual PGCs in zebrafish contribute differentially to gonad development and ovarian reserve, generating both self-renewing GSCs and non-renewing progenitors.

Rbpms2 promotes female fate upstream of the nutrient sensing Gator2 complex component, Mios

The paper identifies Rbpms2 as a regulator of oocyte fate by repressing testis factors and promoting oocyte factors through the Gator2 complex in zebrafish.

Maternal regulation of the vertebrate oocyte-to-egg transition

This paper identifies maternal-effect mutants in zebrafish that reveal molecular mechanisms controlling the oocyte-to-egg transition, focusing on yolk globule formation and protein processing.

Maternal regulation of the vertebrate egg-to-embryo transition

The paper identifies four zebrafish maternal-effect mutants affecting egg-to-embryo transition processes and discovers a novel conserved gene, krang, involved in cortical granule function during egg activation.

Macrophage activation drives ovarian failure and masculization

The paper identifies a macrophage-germline-somatic gonadal cell axis driven by BMP15 mutation that contributes to ovarian failure and masculization in zebrafish.

A Transgenic System for Targeted Ablation of Reproductive and Maternal-Effect genes

The paper develops reverse genetic systems to identify essential maternal-effect genes and tests them by disrupting kif5Ba and bucky ball.

Loss of dmrt1 restores female fates in the absence of cyp19a1a but not rbpms2

The paper shows that cyp19a1a suppresses dmrt1 to establish a bipotential gonad and female fate, with rbpms2 playing a key role in female differentiation.

Zebrafish dazl regulates cystogenesis upstream of the meiotic transition and germline stem cell specification and independent of meiotic checkpoints.

This study shows that zebrafish dazl is essential for cystogenesis, germline stem cell specification, and fertility by regulating incomplete cytokinesis and meiotic entry.