Mitochondrial DNA removal is essential for sperm development and activity
Zhe Chen, Fan Zhang, Annie Lee, Michaela Yamine, Zongheng Wang, Guofeng Zhang, Christian A. Combs, Hong Xu
This study shows that mitochondrial DNA removal is essential for sperm development and activity, revealing a novel exonuclease, ExoA, required for mtDNA elimination and preventing nuclear-mito imbalance.
The EMBO Journal · Feb 11, 2025Peer-reviewedDevelopmental Biology