Author

Jacob M. Hooker

Harvard UniversityORCID 0000-0002-9394-7708Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Adrià SicartiD· 1 shared Alex A. AdornatoiD· 1 shared Anisha BhanotiD· 1 shared Anne S. BerryiD· 1 shared Bruce Robert RoseniD· 1 shared Carlotta BorgarelliiD· 1 shared Emma Lepore Carlson· 1 shared Ermal IsmalajiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperBiochemistry

Adrià SicartORCID

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Author profile →

3 papers

Recent·Most cited

MeFluHyA: a novel fluorescent screening tool for high-throughput identification of HDAC6-selective inhibitors

Yvonne Eileen Klingl, Jozefien Goethals, Adrià Sicart, Carlotta Borgarelli, Joris Van Lindt, Robert Ciarán Prior, Ermal Ismalaj, Wim M. De Borggraeve, Philip Van Damme, Jacob M. Hooker, Michele Curcio, Steven H. L. Verhelst, Matthias Schönberger, Ludo Van Den Bosch

The paper introduces MeFluHyA, a fluorescent probe for identifying HDAC6-selective inhibitors through cell imaging and competitive binding assays.

bioRxiv · Jul 27, 2026 · PreprintBiochemistry

Energetic implications of fMRI-based nodal complex network metrics: a complex picture unfolds across diverse brain states

Shirley Feng, Sean E. Coursey, Sara A. Nolin, Nicole R. Zürcher, Hsiao‐Ying Wey, Jon̈athan R. Polimeni, Marjorie Villien, Anisha Bhanot, Bruce Robert Rosen, Jacob M. Hooker, Jingyuan E. Chen

The paper examines the relationship between fMRI-based network metrics and glucose metabolism across different brain states and diseases, finding state- and network-dependent metabolic associations.

bioRxiv · Jan 9, 2026 · PreprintNeuroscience

Age-Related Changes in Curiosity: The Influence of Locus Coeruleus on Information-Seeking Behavior

Hsiang-Yu Chen, Emma Lepore Carlson, McKenna S. Costello, Johanna Matulonis, Alex A. Adornato, Katherine E. O'Malley, Jacob M. Hooker, Heidi I.L. Jacobs, Anne S. Berry

This study investigates age-related changes in curiosity by examining the role of the locus coeruleus using a novel task, finding that aging shifts curiosity from prediction error-driven to novelty-driven.

bioRxiv · Sep 4, 2025 · PreprintNeuroscience