Heidi I.L. Jacobs

This study examines age-related changes in locus coeruleus-cortical functional connectivity gradients using MRI and PET data, finding reduced functional differentiation in older adults during negative emotional stimuli.

This study shows light modulates locus coeruleus (LC) activity in an emotion-dependent manner, with higher illuminance dampening responses to negative stimuli and enhancing neutral ones.

This study shows that arousal increases locus coeruleus blood flow and modulates brain responses to negative-valence stimuli, while the amygdala shows valence-general responses.

This study investigates age-related changes in curiosity by examining the role of the locus coeruleus using a novel task, finding that aging shifts curiosity from prediction error-driven to novelty-driven.

This study finds older adults show increased locus coeruleus activity and connectivity with dorsolateral prefrontal cortex during ambiguous facial emotion recognition, linked to better mental well-being.

The paper investigates how repeated short light exposures affect sustained pupil responses during different cognitive tasks, finding that higher melanopic irradiance increases pupil responses and that task context influences variability.

This study finds that higher locus coeruleus activity during wakefulness in older adults is linked to worse sleep quality and reduced theta band power during REM sleep.

The paper investigates the relationship between structural and functional characteristics of the locus coeruleus in young and late middle-aged individuals using MRI and finds no association between LC contrast and functional response.