Joris Van Lindt

The paper introduces MeFluHyA, a fluorescent probe for identifying HDAC6-selective inhibitors through cell imaging and competitive binding assays.

This study shows that the SOG1 NAC domain can undergo liquid-liquid phase separation in vitro, dependent on DNA/RNA binding and dimerization.

This study shows that C9orf72-derived arginine-rich dipeptide repeats enhance G3BP1 phase separation, contributing to ALS and FTD pathology.

This study shows that polystyrene sulfonate (PSS) reduces toxicity of ALS-linked dipeptide repeat proteins in cellular and iPSC-derived motor neuron models.

The paper introduces a method to study liquid-liquid phase separation under near-native conditions by using extreme pH to control protein solubility and induce phase separation.