Fungal gasdermin-like proteins are controlled by proteolytic cleavage
Corinne Clavé, Witold Dyrka, Elizabeth A Turcotte, Alexandra Granger‐Farbos, Léa Ibarlosa, Benoı̂t Pinson, Russell E. Vance, Sven J. Saupe, Asen Daskalov
This paper identifies proteolytic cleavage as the mechanism regulating fungal gasdermin activity, showing that HET-Q1 is cleaved by HET-Q2 to induce cell death and that gasdermin genes are clustered with protease genes.
Proceedings of the National Academy of Sciences · Feb 8, 2022Peer-reviewedGenetics