Elizabeth A Turcotte

Strong sustained type I IFN signaling acts cell intrinsically to impair IFNγ responses and cause tuberculosis susceptibility

The paper shows that sustained type I IFN signaling in infected macrophages impairs IFNγ responses, leading to tuberculosis susceptibility.

The gamma-Tubulin Ring Complex promotes mitotic spindle integrity and acts as a microtubule minus-end cap during mitosis

This study shows that gamma-Tubulin Ring Complex (gamma-TuRC) is essential for mitotic spindle integrity, acting both as a nucleator and a minus-end cap.

Shigella OspF blocks rapid p38-dependent priming of the NAIP-NLRC4 inflammasome

This study identifies OspF as a Shigella effector that inhibits NAIP-NLRC4 inflammasome activation by blocking p38-dependent priming, explaining human susceptibility to Shigella.

Fungal gasdermin-like proteins are controlled by proteolytic cleavage

This paper identifies proteolytic cleavage as the mechanism regulating fungal gasdermin activity, showing that HET-Q1 is cleaved by HET-Q2 to induce cell death and that gasdermin genes are clustered with protease genes.