The paper identifies toxin/antidote genes on accessory chromosomes in Fusarium that help maintain these chromosomes and suggests transposable elements contribute to their formation.

Genetics · Sep 19, 2025Peer-reviewedEvolutionary Biology

Amyloid signaling in antiphage defense

Léa Ibarlosa, Sonia Dheur, C. Sánchez, Seamoon Deb, Alexandra Granger‐Farbos, Virginie Coustou, Mélanie Berbon, Aurélie Massoni‐Laporte, Bénédicte Salin, Corinne Blancard, Claire Saragaglia, Xavière Menatong Tene, Nicolas Dufour, Ombeline Rossier, Birgit Habenstein, , Sven J. Saupe

The paper describes an amyloid-based signal transduction mechanism in Escherichia coli's antiphage defense system, showing functional interchangeability between Bab and fungal HET-S amyloids.

Nature Microbiology · Aug 14, 2025Peer-reviewedMicrobiology

Reconstructing NOD-like receptor alleles with high internal conservation in Podospora anserina using long-read sequencing

Sandra Lorena Ament‐Velásquez, Brendan Furneaux, Sonia Dheur, Alexandra Granger‐Farbos, Rike Bahati Stelkens, Hanna Johannesson, Sven J. Saupe

The paper reconstructs NOD-like receptor alleles in Podospora anserina using long-read sequencing, revealing structural and functional insights into incompatibility genes.

Microbial Genomics · Jul 2, 2025Peer-reviewedGenomics

Mitochondrial maintenance is involved in the exceptional longevity of reproductive queens of the eusocial ant Lasius niger

Maïly Kervella, Fabrice Bertile, Alexandra Granger‐Farbos, Benoı̂t Pinson, Alain Schmitt, Martin Quque, Frédéric Bouillaud, François Criscuolo

This study investigates mitochondrial bioenergetics and oxidative stress in queens of Lasius niger, finding that their longevity is associated with better mitochondrial maintenance rather than reduced oxidative damage.

bioRxiv · Jun 27, 2024 · PreprintPhysiology

het-B allorecognition in Podospora anserina is determined by pseudo-allelic interaction of genes encoding a HET and lectin fold domain protein and a PII-like protein

Corinne Clavé, Sonia Dheur, Sandra Lorena Ament‐Velásquez, Alexandra Granger‐Farbos, Sven J. Saupe

This paper identifies the het-B locus in Podospora anserina, showing that incompatibility is determined by non-allelic interaction between Bh1 and Bp2, with the lectin fold domain of BH dictating specificity.

bioRxiv · Dec 19, 2023 · PreprintGenetics

Fungal gasdermin-like proteins are controlled by proteolytic cleavage

Corinne Clavé, Witold Dyrka, Elizabeth A Turcotte, Alexandra Granger‐Farbos, Léa Ibarlosa, Benoı̂t Pinson, Russell E. Vance, Sven J. Saupe, Asen Daskalov

This paper identifies proteolytic cleavage as the mechanism regulating fungal gasdermin activity, showing that HET-Q1 is cleaved by HET-Q2 to induce cell death and that gasdermin genes are clustered with protease genes.

Proceedings of the National Academy of Sciences · Feb 8, 2022Peer-reviewedGenetics

Combinations of Spok genes create multiple meiotic drivers in Podospora

Aaron A. Vogan, Sandra Lorena Ament‐Velásquez, Alexandra Granger‐Farbos, Jesper Svedberg, Eric Bastiaans, Alfons J. M. Debets, Virginie Coustou, Hélène Yvanne, Corinne Clavé, Sven J. Saupe, Hanna Johannesson

The paper identifies Spok genes as the molecular basis of meiotic drivers in Podospora anserina and shows their role in spore killing and resistance through distinct domains.

eLife · Jul 25, 2019Peer-reviewedGenetics