Witold Dyrka

The paper analyzes fungal NLR proteins to identify effector domains and amyloid signaling motifs using bioinformatics and structural prediction tools, revealing new domains and expanded amyloid motif families.

This paper identifies proteolytic cleavage as the mechanism regulating fungal gasdermin activity, showing that HET-Q1 is cleaved by HET-Q2 to induce cell death and that gasdermin genes are clustered with protease genes.

The paper develops probabilistic context-free grammars to detect amyloid signaling motifs across diverse species, showing improved sensitivity and generalization over existing methods.