Sven J. Saupe

NOD-like receptor genes evolve under diversity-enhancing mechanisms in a fungal species complex

This study investigates the evolution of NOD-like receptor (NLR) genes in the Podospora anserina species complex, revealing diversity-enhancing mechanisms and immune-related selective pressures.

The role of toxin/antidote genes in the maintenance and evolution of accessory chromosomes in Fusarium

The paper identifies toxin/antidote genes on accessory chromosomes in Fusarium that help maintain these chromosomes and suggests transposable elements contribute to their formation.

Amyloid signaling in antiphage defense

The paper describes an amyloid-based signal transduction mechanism in Escherichia coli's antiphage defense system, showing functional interchangeability between Bab and fungal HET-S amyloids.

Reconstructing NOD-like receptor alleles with high internal conservation in Podospora anserina using long-read sequencing

The paper reconstructs NOD-like receptor alleles in Podospora anserina using long-read sequencing, revealing structural and functional insights into incompatibility genes.

het-B allorecognition in Podospora anserina is determined by pseudo-allelic interaction of genes encoding a HET and lectin fold domain protein and a PII-like protein

This paper identifies the het-B locus in Podospora anserina, showing that incompatibility is determined by non-allelic interaction between Bh1 and Bp2, with the lectin fold domain of BH dictating specificity.

Exploring a diverse world of effector domains and amyloid signaling motifs in fungal NLR proteins

The paper analyzes fungal NLR proteins to identify effector domains and amyloid signaling motifs using bioinformatics and structural prediction tools, revealing new domains and expanded amyloid motif families.

Fungal gasdermin-like proteins are controlled by proteolytic cleavage

This paper identifies proteolytic cleavage as the mechanism regulating fungal gasdermin activity, showing that HET-Q1 is cleaved by HET-Q2 to induce cell death and that gasdermin genes are clustered with protease genes.

The Enterprise: A massive transposon carrying Spok meiotic drive genes

The paper describes the discovery of a large transposon, Enterprise, in the fungus Podospora anserina, which carries meiotic drive genes and can transpose, challenging views on TE genome impact.

Combinations of Spok genes create multiple meiotic drivers in Podospora

The paper identifies Spok genes as the molecular basis of meiotic drivers in Podospora anserina and shows their role in spore killing and resistance through distinct domains.