Author

Rebecca Roddan

John Radcliffe HospitalORCID 0000-0002-9406-9011Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Joseph A. NewmaniD· 2 shared Peter J. McHughiD· 2 shared Abimael Cruz-MigoniiD· 1 shared Afaf Helmy El-SagheeriD· 1 shared Andrea PierangeliniiD· 1 shared Anna Pérez‐RàfolsiD· 1 shared Annamaria RuggianoiD· 1 shared Bennett Van HouteniD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiochemistry

Joseph A. NewmanORCID

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2 papers

Recent·Most cited

BiochemistryNucleic Acids ResearchPeer-reviewedJul 8, 2025

The dual ubiquitin binding mode of SPRTN secures rapid spatiotemporal proteolysis of DNA-protein crosslinks

Wei Song, Yichen Zhao, Annamaria Ruggiano…·Kristijan Ramadan

This study identifies a ubiquitin-binding domain in SPRTN that enhances its proteolytic activity towards polyubiquitinated DNA-protein crosslinks.

6 citations

experimental assayprotein folding & dynamics

BiochemistrybioRxivPreprintSep 5, 2024

Molecular basis for CSB stimulation of the SNM1A DNA repair nuclease

Rebecca Roddan, Matthew A. Schaich, William J. Nathan…·Peter J. McHugh

This study identifies how CSB enhances SNM1A nuclease activity during ICL repair by interacting with its nuclease core and altering substrate conformation.

2 citations

humanDNA methylation