Author

Wei Song

John Radcliffe HospitalORCID 0000-0002-2834-5671Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Wei Song3 papers · Beijing Institute of Technology

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Kristijan RamadaniD· 3 shared Christina RedfieldiD· 2 shared Joseph A. NewmaniD· 2 shared P.R. ElliottiD· 2 shared Abimael Cruz-MigoniiD· 1 shared Alvin Wei Tian NgiD· 1 shared Andrea PierangeliniiD· 1 shared Anna Pérez‐RàfolsiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBiochemistry

Kristijan RamadanORCID

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3 papers

Recent·Most cited

Nucleophagy removes cytotoxic trapped PARP1

Gwendoline Hoslett, Sara Tribble, Pauline Lascaux, Stelios Koukouravas, Ignacio Torrecilla, Wei Song, Cynthia X. Hou, Xia Li, Martín González Fernández, Giuliana De Gregoriis, Rebecca A. Dagg, Darragh Patrick O'Brien, Andrea Pierangelini, Thibaud Martial, Alvin Wei Tian Ng, , Kristijan Ramadan

This study identifies nucleophagy as the mechanism by which trapped PARP1 is cleared, showing that inhibiting this process re-sensitizes PARPi-resistant cells to PARPi.

Nature Cell Biology · Jun 1, 2026Peer-reviewedCell Biology

DNA-induced conformational changes in SPRTN relieve its auto-inhibitory effect on protease activity

Wei Song, Joseph A. Newman, Yichen Zhao, Rod Chalk, Christina Redfield, P.R. Elliott, Kristijan Ramadan

This study reveals how DNA-induced conformational changes in SPRTN relieve its auto-inhibitory effect on protease activity, enabling efficient DPC proteolysis.

bioRxiv · May 1, 2026 · PreprintBiochemistry

The dual ubiquitin binding mode of SPRTN secures rapid spatiotemporal proteolysis of DNA-protein crosslinks

Wei Song, Yichen Zhao, Annamaria Ruggiano, Christina Redfield, Joseph A. Newman, Xiaosheng Zhu, Marta García‐Flores, Abimael Cruz-Migoni, Rebecca Roddan, Anna Pérez‐Ràfols, Peter J. McHugh, P.R. Elliott, Kristijan Ramadan

This study identifies a ubiquitin-binding domain in SPRTN that enhances its proteolytic activity towards polyubiquitinated DNA-protein crosslinks.

Nucleic Acids Research · Jul 8, 2025Peer-reviewedBiochemistry