Author

Peter J. McHugh

John Radcliffe HospitalORCID 0000-0002-8679-4627Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:DNA methylation· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:proteomics· 1

Frequent Co-Authors

Joseph A. NewmaniD· 2 shared Rebecca RoddaniD· 2 shared William J. NathaniD· 2 shared Abimael Cruz-MigoniiD· 1 shared Afaf Helmy El-SagheeriD· 1 shared André NussenzweigiD· 1 shared Andrea PierangeliniiD· 1 shared Andrés Canela· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersBiochemistry

Joseph A. NewmanORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The dual ubiquitin binding mode of SPRTN secures rapid spatiotemporal proteolysis of DNA-protein crosslinks

Wei Song, Yichen Zhao, Annamaria Ruggiano, Christina Redfield, Joseph A. Newman, Xiaosheng Zhu, Marta García‐Flores, Abimael Cruz-Migoni, Rebecca Roddan, Anna Pérez‐Ràfols, Peter J. McHugh, P.R. Elliott, Kristijan Ramadan

This study identifies a ubiquitin-binding domain in SPRTN that enhances its proteolytic activity towards polyubiquitinated DNA-protein crosslinks.

Nucleic Acids Research · Jul 8, 2025Peer-reviewedBiochemistry

Molecular basis for CSB stimulation of the SNM1A DNA repair nuclease

Rebecca Roddan, Matthew A. Schaich, William J. Nathan, Iulia Kis, Andrea Pierangelini, Lucy R. Henderson, Raman van Wee, Louise Martin, Afaf Helmy El-Sagheer, Philipp Kukura, Tom P Brown, Darragh Patrick O'Brien, Joseph A. Newman, David M. Wilson, Christopher John Schofield, , Peter J. McHugh

This study identifies how CSB enhances SNM1A nuclease activity during ICL repair by interacting with its nuclease core and altering substrate conformation.

bioRxiv · Sep 5, 2024 · PreprintBiochemistry

Neuronal Enhancers are Hotspots For DNA Single-Strand Break Repair

Wei Wu, Sarah E. Kargbo-Hill, William J. Nathan, Jacob Paiano, Elsa Callén, Dongpeng Wang, Kenta Shinoda, Niek van Wietmarschen, J Colon, Dali Zong, Raffaella De Pace, Han‐Yu Shih, Steven L. Coon, Maia Parsadanian, Raphael Pavani, , André Nussenzweig

The paper identifies DNA single-strand breaks (SSBs) accumulating at neuronal enhancers and shows their repair involves PARP1, XRCC1, and DNA polymerase β.

Nature · Mar 25, 2021Peer-reviewedNeuroscience