BiophysicsProceedings of the National Academy of SciencesPeer-reviewed
Residues 2-7 of alpha-synuclein regulate amyloid formation via lipid-dependent and -independent pathways
Katherine M. Dewison, Benjamin Rowlinson, Jonathan M. Machin…·Sheena E. Radford
This study identifies residues 2-7 of alpha-synuclein as regulators of amyloid formation, showing they slow fibril formation and reduce aggregation in vitro and in vivo without affecting membrane binding.
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