Joel A. Crossley

FENNEC classifies bursts in diffusion-based smFRET data into conformational dynamics and photophysical artefacts using simulated data, without requiring labeled experimental data.

This study uses nanopipette electrospray ionisation ion mobility mass spectrometry to investigate how buffer conditions affect α-synuclein conformational dynamics.

This study identifies residues 2-7 of alpha-synuclein as regulators of amyloid formation, showing they slow fibril formation and reduce aggregation in vitro and in vivo without affecting membrane binding.