Visualizing the Dominant GPCR Coupling of Pathogenic Gαo Mutants in GNAO1-Related Disorders
Yonika Arum Larasati, Camille Rabesahala de Meritens, Miriam Stoeber, Vladimir L. Katanaev, Gonzalo P. Solis
This study uses a split-YFP BiFC assay to show that severe GNAO1 mutations impair GPCR disengagement, while milder mutants show near-normal receptor internalization.
The FASEB Journal · Dec 29, 2025Peer-reviewedCell Biology