Vladimir L. Katanaev

Visualizing the Dominant GPCR Coupling of Pathogenic Gαo Mutants in GNAO1-Related Disorders

This study uses a split-YFP BiFC assay to show that severe GNAO1 mutations impair GPCR disengagement, while milder mutants show near-normal receptor internalization.

Cortical neurons obtained from patient-derived iPSCs with GNAO1 p.G203R variant show altered differentiation and functional properties

This study uses patient-derived iPSCs with a GNAO1 variant to show altered neuronal differentiation and function in cortical neurons.

Humanization of Drosophila Gαo to model GNAO1 paediatric encephalopathies

This paper humanizes the Drosophila Gαo gene to create a model for GNAO1-related paediatric encephalopathies, enabling functional studies of disease-causing mutations.