ImmunologyScience AdvancesPeer-reviewed
TET2 regulates early and late transitions in exhausted CD8+ T-cell differentiation and limits CAR T-cell function
Alexander J. Dimitri, Amy E. Baxter, Gregory M. Chen…·Joseph A. Fraietta
This study shows that targeting TET2 in CAR T-cells improves their anti-tumor responses by limiting terminal exhaustion and enhancing therapeutic potential.