This study identifies sorcin as a factor linking annexin A11 to ESCRT-III assembly during plasma membrane repair, showing Ca2+-dependent scaffolding at sites of damage.

Proceedings of the National Academy of Sciences · Aug 10, 2026Peer-reviewedCell Biology

p62 sorts Lupus La and selected microRNAs into breast cancer-derived exosomes

Jordan Matthew Ngo, Justin Krish Williams, Morayma M. Temoche-Diaz, Abinayaa Murugupandiyan, Randy W. Schekman

The paper identifies p62 as a factor that sorts La and miR-122 into exosomes, showing its role in modulating exosomal miRNA composition and promoting tumor growth.

The Journal of Cell Biology · Nov 25, 2025Peer-reviewedCell Biology

Endosome transcriptomics reveal trafficking of Cajal bodies into multivesicular bodies

Jasleen Singh, Justin Krish Williams, Quinn Elliott, Rohit Jhawar, Lucas Ferguson, Kathleen Collins, Randy W. Schekman

The paper identifies nuclear small regulatory RNAs in multivesicular bodies and shows their trafficking requires ESCRT machinery but not LC3 lipidation.

Proceedings of the National Academy of Sciences · Oct 8, 2025Peer-reviewedBiochemistry

Calpains Orchestrate Secretion of Annexin-containing Microvesicles during Membrane Repair

Justin Krish Williams, Jordan Matthew Ngo, Abinayaa Murugupandiyan, Dorothy E. Croall, H. Criss Hartzell, Randy W. Schekman

The paper identifies calpains as key regulators of annexin-containing microvesicle secretion during plasma membrane repair, showing cleavage of annexins facilitates their release as MVs.

The Journal of Cell Biology · Apr 3, 2025Peer-reviewedCell Biology

Annexin A6 mediates calcium-dependent secretion of exosomes

Justin Krish Williams, Jordan Matthew Ngo, Isabelle Madeline Lehman, Randy W. Schekman

The paper identifies annexin A6 as a protein required for Ca2+-dependent exosome secretion during plasma membrane repair.

eLife · May 19, 2023Peer-reviewedMolecular Biology