Randy W. Schekman

This study identifies sorcin as a factor linking annexin A11 to ESCRT-III assembly during plasma membrane repair, showing Ca2+-dependent scaffolding at sites of damage.

This study conducts a genome-wide association study of copy number variations in Parkinson's disease, identifying a significant PRKN deletion but limited replication in an independent dataset.

The paper identifies p62 as a factor that sorts La and miR-122 into exosomes, showing its role in modulating exosomal miRNA composition and promoting tumor growth.

The paper identifies nuclear small regulatory RNAs in multivesicular bodies and shows their trafficking requires ESCRT machinery but not LC3 lipidation.

The paper identifies calpains as key regulators of annexin-containing microvesicle secretion during plasma membrane repair, showing cleavage of annexins facilitates their release as MVs.

This study engineers a minimal EDV for genome editing by removing viral components, showing improved efficiency and reduced size.

The paper identifies annexin A6 as a protein required for Ca2+-dependent exosome secretion during plasma membrane repair.