Author

Thomas M. Sparks

Max Delbrück CenterORCID 0000-0002-9455-8309Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:Hi-C· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Alexander KukaleviD· 2 shared Ana PomboiD· 2 shared Christoph J. ThiemeiD· 2 shared Gesa LoofiD· 2 shared Rieke KempferiD· 2 shared Amanda G. FisheriD· 1 shared Anja WeiseiD· 1 shared Anna‐Katerina HadjantonakisiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersGenomics

Alexander KukalevORCID

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2 papers

Recent·Most cited

Extensive folding variability between homologous chromosomes in mammalian cells

Ibai Irastorza-Azcárate, Alexander Kukalev, Rieke Kempfer, Christoph J. Thieme, Guido Mastrobuoni, Julia Markowski, Gesa Loof, Thomas M. Sparks, Emily Brookes, Kedar Nath Natarajan, Stephan Sauer, Amanda G. Fisher, Mario Nicodemi, Bing Ren, Roland F. Schwarz, , Ana Pombo

The paper uses GAM to study haplotype-specific 3D chromatin structures in mESCs, finding extensive allelic differences in chromatin architecture and gene expression mediated by Polycomb repression.

Molecular Systems Biology · May 6, 2025Peer-reviewedGenomics

3D genome topologies distinguish pluripotent epiblast and primitive endoderm cells in the mouse blastocyst

Gesa Loof, Dominik Szabó, Vidur Garg, Alexander Kukalev, Luna Zea-Redondo, Rieke Kempfer, Thomas M. Sparks, Yingnan Zhang, Christoph J. Thieme, Sílvia Carvalho, Anja Weise, Milash Balachandran, Thomas Liehr, Lonnie R. Welch, Anna‐Katerina Hadjantonakis, Ana Pombo

The paper examines 3D genome structures in mouse blastocyst cells to identify lineage-specific chromatin organization differences between epiblast and primitive endoderm cells.

bioRxiv · Oct 19, 2022 · PreprintDevelopmental Biology