Vidur Garg

ETV4 and ETV5 Orchestrate FGF-Mediated Lineage Specification and Epiblast Maturation during Early Mouse Development

This study shows that ETV4 and ETV5 regulate lineage specification and embryo patterning in mice by affecting primitive endoderm formation and pluripotency exit.

Amino acid intake strategies define pluripotent cell states

This study shows that mouse embryonic stem cells (ESCs) can proliferate without essential amino acids by taking up and digesting exogenous protein, mimicking pre-implantation embryos.

Systematic mapping and modeling of 3D enhancer-promoter interactions in early mouse embryonic lineages reveal regulatory principles that determine the levels and cell-type specificity of gene expression

Single-cell analysis of bidirectional reprogramming between early embryonic states reveals mechanisms of differential lineage plasticities

The paper uses single-cell RNA and ATAC-seq to study bidirectional reprogramming between embryonic states, revealing differences in lineage plasticity.

3D genome topologies distinguish pluripotent epiblast and primitive endoderm cells in the mouse blastocyst

The paper examines 3D genome structures in mouse blastocyst cells to identify lineage-specific chromatin organization differences between epiblast and primitive endoderm cells.

SARS-CoV-2 Can Infect Human Embryos

This study shows SARS-CoV-2 can infect human embryos, specifically trophectoderm cells in blastocysts, with potential implications for reproductive health.

Charting the emergent organotypic landscape of the mammalian gut endoderm at single-cell resolution

The paper maps the developmental trajectories of endoderm cells in the mouse embryo to reveal lineage relationships and spatial organization during gut formation.