Rieke Kempfer

The paper integrates 4D Nucleome data to analyze 3D genome structure and function in human cells, revealing chromatin domains, loops, and interactions, and showing how genetic variants affect genome folding.

The paper uses GAM to study haplotype-specific 3D chromatin structures in mESCs, finding extensive allelic differences in chromatin architecture and gene expression mediated by Polycomb repression.

The paper introduces multiplex-GAM, a ligation-free method for genome-wide chromatin contact mapping, showing it detects different strong contacts compared to Hi-C, particularly involving active genomic regions.

The paper examines 3D genome structures in mouse blastocyst cells to identify lineage-specific chromatin organization differences between epiblast and primitive endoderm cells.

GAMIBHEAR reconstructs haplotypes from Genome Architecture Mapping data to enable allele-specific chromatin conformation analysis.

The paper uses sci-ATAC-seq and a new tool, ScregSeg, to analyze chromatin dynamics in zebrafish embryos, revealing roles of npas4l/cloche in cell and regulatory states.

The paper investigates cell-type specific 3D chromatin structures in the brain using immunoGAM, finding TAD melting, neuron-specific contacts, and compartmentalization patterns related to gene expression and neurodegenerative diseases.

The paper identifies sex-specific differences in meiotic regulation in C. elegans, showing that female meiosis has stricter checkpoints and different responses to synapsis defects compared to males.