Hannah C. Schriever

Zebrafish optic nerve injury results in systemic retinal ganglion cell dedifferentiation

This study shows that zebrafish retinal ganglion cells dedifferentiate after optic nerve injury, resembling immature RGCs, and identifies potential therapeutic targets for human RGC protection.

tet2 and tet3 regulate cell fate specification and differentiation events during retinal development

The paper investigates the role of Tet2 and Tet3 in retinal development using scRNA-seq, identifying defects in cell fate specification and differentiation.

Decreased GABA levels during development result in increased connectivity in the larval zebrafish tectum

This study shows that reduced GABA levels during development increase functional connectivity and hyper-synchronization in the larval zebrafish optic tectum.

Vaeda computationally annotates doublets in single-cell RNA sequencing data

Vaeda annotates doublets in scRNA-seq data using a variational auto-encoder and Positive-Unlabeled learning, performing competitively and outperforming Python-based methods.

Computational profiling of hiPSC-derived heart organoids reveals chamber defects associated with Ebstein's anomaly

The paper develops heart organoids and uses computational methods to model Ebstein's anomaly by analyzing single-cell RNA sequencing data from organoids with genetic variants.