Abha Singh Bais

Mitotic Block and Epigenetic Repression Underlie Neurodevelopmental Defects and Neurobehavioral Deficits in Congenital Heart Disease

This study identifies mitotic block and epigenetic repression as causes of neurodevelopmental defects and neurobehavioral deficits in congenital heart disease using mouse models.

Spatial transcriptome profiling uncovers metabolic regulation of left-right patterning

The paper identifies metabolic regulation in left-right patterning using spatial transcriptome data, linking glycolysis and Bmp7 to heart and gut looping.

Single cell RNA sequencing reveals differential cell cycle activity in key cell populations during nephrogenesis

This study uses single-cell RNA sequencing to identify differential cell cycle activity in nephron progenitors during mouse kidney development, highlighting Birc5 as a potential key molecule in nephron patterning.

Computational profiling of hiPSC-derived heart organoids reveals chamber defects associated with Ebstein's anomaly

The paper develops heart organoids and uses computational methods to model Ebstein's anomaly by analyzing single-cell RNA sequencing data from organoids with genetic variants.

scds: Computational Annotation of Doublets in Single Cell RNA Sequencing Data

The paper introduces scds, a tool for identifying doublets in scRNA-seq data, with two methods that perform competitively with existing approaches at lower computational cost.