Guang Li

Overcoming segmentation bottlenecks in brain tissue for spatial proteomic inference at population scale

The paper introduces SPInfer, a workflow for spatial proteomic inference that improves cell segmentation in human brain tissue, enabling better biological discovery at population scale.

Unbiased and Epicardial-Specific Lineage Tracing Reveal Epicardial Contribution to Vascular Endothelial Cells in Heart Development

The paper identifies epicardial cells' contribution to vascular endothelial cells in heart development using a CRISPR-based lineage-tracing system and a novel marker gene, Lrrn4.

Cited4a limits cardiomyocyte dedifferentiation and proliferation during zebrafish heart regeneration

This study identifies cited4a as a regulator that suppresses cardiomyocyte dedifferentiation and proliferation during zebrafish heart regeneration.

Heart spheroids from primary cells for studying cardiac development

This study generates heart spheroids from murine primary cells and shows they retain in vivo cell lineages and respond to growth factors and cell interactions.

Cardiac Fibroblasts regulate myocardium and coronary vasculature development via the collagen signaling pathway

This study identifies the role of cardiac fibroblasts in regulating myocardium and coronary vasculature development through the collagen signaling pathway using genetic ablation and single-cell RNA sequencing.

Heterogeneity and Functional Analysis of Cardiac Fibroblasts in Heart Development

This study identifies developmental heterogeneity in cardiac fibroblasts and their functional roles through single-cell RNA sequencing and ablation experiments.

Foxm1 drives cardiomyocyte proliferation in adult zebrafish after cardiac injury

This study identifies foxm1 as essential for cardiomyocyte proliferation in adult zebrafish after injury, revealing its role in regulating cell cycle genes and enabling regeneration.

Molecular hallmarks of heterochronic parabiosis at single cell resolution

This study uses single-cell RNA-sequencing to analyze cell type-specific responses to young or aged blood in heterochronic parabiosis, identifying mitochondrial function as a key factor in rejuvenation.

Computational profiling of hiPSC-derived heart organoids reveals chamber defects associated with Ebstein's anomaly

The paper develops heart organoids and uses computational methods to model Ebstein's anomaly by analyzing single-cell RNA sequencing data from organoids with genetic variants.